SPTC2 Rabbit Polyclonal Antibody, 20ul Vacuum Filter ALK/SQSTM1 (chromosome 5)

ALK/SQSTM1 (chromosome 5)

Binds to DNA sequences containing the consensus nucleotide core sequence GGAA

A related pseudogene has been identified on chromosome 7

Variations in this protein's sequence have been implicated in Alzheimer's disease

Pseudogenes of this gene have been identified on multiple chromosomes

SPTC2 Rabbit Polyclonal Antibody, 20ul Vacuum Filter ALK/SQSTM1 (chromosome 5)This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase which consists of two different subunits is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal 5 prime phosphate dependent condensation of L serine and palmitoyl CoA to 3 oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.