ATG4a Rabbit Polyclonal Antibody, 20ul Protein Post-translational Modification The encoded nuclear protein represses

The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells

It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation| DNA repair| and/or cell cycle checkpoint control

Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability

It contains a basic region-leucine zipper (bZIP)-like domain

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins| including proteins that are associated with neurodegenerative and metabolic disease

ATG4a Rabbit Polyclonal Antibody, 20ul Protein Post-translational Modification The encoded nuclear protein repressesAutophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene