Rb(Phospho Ser608) Polyclonal Antibody, 100ul Protein Analysis subunit:Interacts with guanylate kinase-like domain

subunit:Interacts with guanylate kinase-like domain of DLG1

Apoptosis antagonizing transcription factor encoded by AATF was identified on the basis of its interaction with MAP3K12/DLK

It can also form heterodimers with the related protein CEBP-delta

This receptor associates with guanine-nucleotide-binding (G) proteins

The acidic C-terminal region of the encoded protein can act as a transactivation domain

Rb(Phospho Ser608) Polyclonal Antibody, 100ul Protein Analysis subunit:Interacts with guanylate kinase-like domainThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.