Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler The N-terminal FADD-like death effector

The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD

Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity

This gene is the cellular homolog of viral raf gene (v-raf)

There is a microRNA gene located within the 5' exon of this gene

The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes

Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler The N-terminal FADD-like death effectorThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.