ANO5 Rabbit Polyclonal Antibody, 50ul ADME Studies in mouse suggest that

Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA

May exert this function by promoting GLI1 nuclear localization

Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues

Also expressed in certain liver and kidney carcinomas

ANO5 Rabbit Polyclonal Antibody, 50ul ADME Studies in mouse suggest thatThis gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described.