Rb Polyclonal Antibody, 50ul[BT-AP07694] Antibody Development induction:By mitogens

induction:By mitogens

Peutz-Jeghers syndrome

which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2

which is composed of eight protein subunits and highly conserved in eukaryotic cells

Gene Ontology (GO) annotations related to this gene include calmodulin binding and Ras GTPase binding

Rb Polyclonal Antibody, 50ul[BT-AP07694] Antibody Development induction:By mitogensThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.