Stat5 Polyclonal Antibody, 20ul[BT-AP08635] Protein Post-translational Modification food intake and development

food intake and development

see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation

Transcriptional repressor that binds to the promoter region of target genes

Alternative splicing of SRPK1 results in multiple transcript variants

Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability

Stat5 Polyclonal Antibody, 20ul[BT-AP08635] Protein Post-translational Modification food intake and developmentStat5 is activated in response to a wide variety of ligands including IL 2, GM CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL 3, which suggests its involvement in angiogenesis and cell motility.