LIMK-2 Polyclonal Antibody, 50ul[BT-AP05022] Serum also designated High-glucose-regulated protein 8

also designated High-glucose-regulated protein 8

Mutations in this gene cause coenzyme Q10 deficiency| a mitochondrial encephalomyopathy| and also COQ2 nephropathy| an inherited form of mitochondriopathy with primary renal involvement

The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex

Ile654/Ile655

The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions| where they appear to provide protective functions

LIMK-2 Polyclonal Antibody, 50ul[BT-AP05022] Serum also designated High-glucose-regulated protein 8There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein protein interactions. LIM kinase 1 and LIM kinase 2 belong to a small subfamily with a unique combination of 2 N terminal LIM motifs and a C terminal protein kinase