Mdm2 Polyclonal Antibody, 20ul[BT-AP05302] Metabolic enzymes A related mRNA suggests an

A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence

one found in pancreatic islet beta cells and two found in liver

but was not secreted

an acid and a nucleophile

This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes

Mdm2 Polyclonal Antibody, 20ul[BT-AP05302] Metabolic enzymes A related mRNA suggests anMDM2 encodes a nuclear localized E3 ubiquitin ligase. E3 ubiquitin protein ligase Mdm2 can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript