IGF-IR(Phospho Tyr1161) Polyclonal Antibody, 20ul[BT-AP08809] Culture Plate Inserts Among its related pathways are

Among its related pathways are Developmental Biology and Adherens junction

while decreased activity leads to hypofibrinolysis

Mutations in OCRL cause oculocerebrorenal syndrome of Lowe and also Dent disease

The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3)

Related pseudogenes have been identified on chromosomes 3 and 7

IGF-IR(Phospho Tyr1161) Polyclonal Antibody, 20ul[BT-AP08809] Culture Plate Inserts Among its related pathways areThis receptor binds insulin like growth factor with a high affinity. It has tyrosine kinase activity. The insulin like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have