p53(Phospho Ser15) Polyclonal Antibody, 50ul Filtration proteolytic cleavage of the non-collagenous

proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten

Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2

Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene

Interacts with IRS4 (phosphorylated)

The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development

p53(Phospho Ser15) Polyclonal Antibody, 50ul Filtration proteolytic cleavage of the non-collagenousThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.