Human Histone H2A Type 2-C, HIST2H2AC ELISA Kit, 96T Sealing Film The protein encoded by CCNE2

The protein encoded by CCNE2 (cyclin E2)belongs to the highly conserved cyclin family

It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters

CCNC and CDK8 subunits form a distinct module termed the CDK8 module

A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis

Keratin 20 encoded by KRT20 is a member of the keratin family

Human Histone H2A Type 2-C, HIST2H2AC ELISA Kit, 96T Sealing Film The protein encoded by CCNE2Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post translational modifications of histones, also called histone code, and nucleosome remodeling.