NEDD4L(Phospho-Ser448) Rabbit Polyclonal Antibody, 20ul PCR Series Defects in PAK3 are the

Defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30 (MRX30)

The enzymes display overlapping but distinct substrate specificity

a type II transmembrane TNF superfamily member with high identity to TNF in its extracellular portion

3) associated with gonadal dysgenesis and XY sex reversal

C-reactive protein encoded by CRP belongs to the pentaxin family

NEDD4L(Phospho-Ser448) Rabbit Polyclonal Antibody, 20ul PCR Series Defects in PAK3 are theThis gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin conjugating enzymes to protein substrates thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial