Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Required for proper 27S pre-rRNA

Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly

This protein mediates the signals of the bone morphogenetic proteins (BMPs)| which are involved in a range of biological activities including cell growth| apoptosis| morphogenesis| development and immune responses

Eight alternatively spliced transcript variants have been described

subcellular location:Expressed diffusely throughout the nucleus

Translocations between MLF1 and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia

Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Required for proper 27S pre-rRNAThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.