RN123 Polyclonal Antibody, 50ul Antibody Development CDK8 and CDC2L6/CDK11

CDK8 and CDC2L6/CDK11

This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids

Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex

Contains 1 DENN domain

and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27

RN123 Polyclonal Antibody, 50ul Antibody Development CDK8 and CDC2L6/CDK11The protein encoded by this gene contains a C terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein protein and protein DNA interactions, and an N terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants.