Crk II Monoclonal Antibody, 50ul[BT-MCA0386] Vortex Mixer Mice that do not express

Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis

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Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing

but is properly located on chromosome 6

Multiple alternatively spliced transcript variants have been reported for this gene

Crk II Monoclonal Antibody, 50ul[BT-MCA0386] Vortex Mixer Mice that do not expressThis gene encodes a member of an adapter protein family that binds to several tyrosine phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2 phosphotyrosine interaction. The N terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C