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The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development

is a multiprotein complex composed of at least ten nonidentical subunits

Reduced expression of this protein has been implicated in cardiomyopathies

This gene is located in the male-specific region of the Y chromosome

p53(Phospho Ser378) Polyclonal Antibody, 100ul Sealing Film Don't hold back - pushThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.