Endothelin B Receptor Polyclonal Antibody, 50ul Primary Antibodies SH3 domains

SH3 domains

The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1|4|5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors

Multiple alternatively spliced variants| encoding the same protein| have been identified

Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4

This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus

Endothelin B Receptor Polyclonal Antibody, 50ul Primary Antibodies SH3 domainsThe protein encoded by this gene is a G protein coupled receptor which activates a phosphatidylinositol calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple