CEP55(Phospho Ser425) Polyclonal Antibody, 50ul Plates & Dishes PTM:Auto-ubiquitinated upon EGF-mediated cell activation

PTM:Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28

The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt

Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress

The protein encoded by IGFALS is a serum protein that binds insulin-like growth factors

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CEP55(Phospho Ser425) Polyclonal Antibody, 50ul Plates & Dishes PTM:Auto-ubiquitinated upon EGF-mediated cell activationPlays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.,PTM: There is a hierachy of phosphorylation, where both Ser 425 and Ser 428 are phosphorylated at the onset of mitosis, prior to Ser 436. Phosphorylation at Ser 425 and Ser 428 is required for dissociation from the centrosome at the G2 M boundary. Phosphorylation at the 3 sites, Ser 425, Ser 428 and Ser 436,