FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture Two alternatively spliced transcript variants

Two alternatively spliced transcript variants encoding distinct isoforms have been described

which is part of the response to intracellular nitric oxide

GPNMB may be involved in growth delay and reduction of metastatic potential

that may share one or more domains in common

The encoded protein plays a role in the inducible expression of cytokine genes in T cells| especially in the induction of interleukin-2 and interleukin-4

FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture Two alternatively spliced transcript variantsdisease: A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X; 11)(q13; q23) with MLL HRX. The result is a rogue activator protein. Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin response elements (IREs) and can activate transcription of IGFBP1. Down regulates expression of HIF1A and suppresses hypoxia induced transcriptional activation of HIF1A modulated genes.