Rat Cyclin-dependent Kinase 4, CDK-4 ELISA Kit, 96T Drying & Desiccation Alternative splicing of NR3C results

Alternative splicing of NR3C results in transcript variants encoding either the same or different isoforms

a member of the MAP kinase family

Involved in cell cycle regulation: required for entry into S phase and cytokinesis

The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate

Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives

Rat Cyclin-dependent Kinase 4, CDK-4 ELISA Kit, 96T Drying & Desiccation Alternative splicing of NR3C resultsSer Thr kinase component of cyclin D CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell cycle during G(1) S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in