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Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers

Interacts with AKAP9

|subunit:Interacts with a receptor composed of CRLF2 and IL7R

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CRLF1 Polyclonal Antibody, 50ul Pathway and Network Analysis Experience precision filtration like neverThis gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold induced sweating syndrome.