CDC2 Monoclonal Antibody, 50ul[BT-MCA0323] Serum & Sample Tubes Mutations in APP have been

Mutations in APP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy)

The encoded protein contains one homeobox and nine zinc finger domains

and water and ion flux in lung and intestinal epithelia

Localizing to intracellular compartments such as the Golgi apparatus

This gene is one of a cluster of highly related genes located at chromosomal region 19q13

CDC2 Monoclonal Antibody, 50ul[BT-MCA0323] Serum & Sample Tubes Mutations in APP have beenThe protein encoded by this gene is a member of the Ser Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M phase promoting factor (MPF), which is essential for G1 S and G2 M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and