SACS Polyclonal Antibody, 20ul sgRNA Oligos Studies of the mouse homolog

Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways

Additional splice variation has been identified but the full-length nature of these transcripts has not been determined

The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017)

around which approximately 146 bp of DNA is wrapped in repeating units

The precise function of this gene is unknown

SACS Polyclonal Antibody, 20ul sgRNA Oligos Studies of the mouse homologThis gene encodes the sacsin protein, which includes a UbL domain at the N terminus, a DnaJ domain, and a HEPN domain at the C terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12. 8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix Saguenay (ARSACS), a neurodegenerative