HLA Class I Polyclonal Antibody, 50ul[BT-AP10062] Bottle-Top Dispenser the encoded protein localizes to

the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains

Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit

The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors

In adults| higher level expression is seen in the placenta| lung| kidney| and pancreas than in the heart| brain| liver and skeletal muscle

this protein is cleaved in a caspase-dependent way

HLA Class I Polyclonal Antibody, 50ul[BT-AP10062] Bottle-Top Dispenser the encoded protein localizes toHLA A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon