IGF-IIR Polyclonal Antibody, 100ul[BT-AP04394] Transporters Cell surface expression is lost

Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation

subunit:Interacts with FGFR1 and FGFR4

Mutations in this gene cause coenzyme Q10 deficiency| a mitochondrial encephalomyopathy| and also COQ2 nephropathy| an inherited form of mitochondriopathy with primary renal involvement

This protein plays a role in regulating cell migration

where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein

IGF-IIR Polyclonal Antibody, 100ul[BT-AP04394] Transporters Cell surface expression is lostIGF2R encodes a receptor for both insulin like growth factor 2 and mannose 6 phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with