NBK(Phospho Ser35) Polyclonal Antibody, 20ul Roller Bottles The paraplegin gene is responsible

The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia

not all variants have been fully characterized

The encoded protein has a signal peptide that is cleaved to release the mature peptide

resulting from the use of alternate polyadenylation signals

and it is the ligand for two proteins at the cell surface of T cells

NBK(Phospho Ser35) Polyclonal Antibody, 20ul Roller Bottles The paraplegin gene is responsibleThe protein encoded by this gene shares a critical BH3 domain with other death promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro apoptotic activity, and for interaction with anti apoptotic members of the BCL2 family, and viral survival promoting proteins. Since the activity of this protein is suppressed in the presence of survival promoting proteins, it is suggested as a likely target for anti apoptotic proteins.