ADAM10 Polyclonal Antibody, 50ul PCR Series a putative tumor suppressor associated

a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1

This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells| however

are located closely on chromosome 11

Constitutive activation of this gene caused either by somatic mutations

This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development

ADAM10 Polyclonal Antibody, 50ul PCR Series a putative tumor suppressor associatedMembers of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. ADAM10 encodes and ADAM family member that cleaves many proteins including TNF alpha and E cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing.