Sgo1 Polyclonal Antibody, 50ul Custom DNA Oligos IGFBP7 encodes a member of

IGFBP7 encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family

This gene encodes the cytosolic isozyme

Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism

Among its related pathways are Sweet Taste Signaling

Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12)

Sgo1 Polyclonal Antibody, 50ul Custom DNA Oligos IGFBP7 encodes a member ofShugoshin like 1 encoded by SGOL1 is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found