Rb(Phospho Thr826) Polyclonal Antibody, 50ul Pipette Controller and mutations in MYOC have

and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma

Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS)| which involves increased risk of cancers including malignant mesothelioma| uveal melanoma and cutaneous melanoma

When bound to ligands

2002 [PubMed 11836249])

Chloride channels play important roles in the plasma membrane and in intracellular organelles

Rb(Phospho Thr826) Polyclonal Antibody, 50ul Pipette Controller and mutations in MYOC haveThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.