Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter MLH3 is a member of

MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes

Involved in protein trafficking

The protein localizes to cell membranes

COP9 signalosome complex subunit 5 encoded by COPS5 is one of the eight subunits of COP9 signalosome

We propose that human ACBD6 represents a cellular marker for primitive progenitor cells with functions in hematopoiesis and vascular endothelium development

Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter MLH3 is a member ofMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.