NPM(Phospho-Thr95) Rabbit Polyclonal Antibody, 100ul Pipette Holder Take a risk with this

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Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis

and thus may play a role in the response to environmental stress and cytokines

This protein is a molecular chaperone with specific function in cell signal transduction

In a conventional activation pathway| I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators| subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus

NPM(Phospho-Thr95) Rabbit Polyclonal Antibody, 100ul Pipette Holder Take a risk with thisThis gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF p53 pathway. A number of genes are fusion partners have been characterized in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified.