HBM Polyclonal Antibody, 50ul Cell Separation and Collection Diseases associated with MARK1 include

Diseases associated with MARK1 include tauopathy and alzheimer disease

resulting in the reconfiguration of cadherin-actin filament connections

DNA damage inducible transcript 3 functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members

Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity

HBM Polyclonal Antibody, 50ul Cell Separation and Collection Diseases associated with MARK1 includeThe human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5' zeta pseudozeta mu pseudoalpha 1 alpha 2 alpha 1 theta 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein coding gene.