CHST5 Polyclonal Antibody, 50ul Human Genome Knockout Libraries It is very conserved in

It is very conserved in evolution

Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome

This protein interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators

more specifically the alpha q subfamily of G proteins

This gene is a member of a conserved family of genes that share a common DNA-binding domain

CHST5 Polyclonal Antibody, 50ul Human Genome Knockout Libraries It is very conserved inThe protein encoded by this gene belongs to the Gal GalNAc GlcNAc 6 O sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N acetylgalactosamine (GalNAc), or N acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O linked sugars of mucin type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in