FA83H Rabbit Polyclonal Antibody, 50ul Enzyme-Linked Immunosorbent Assay (ELISA) Sodium bicarbonate cotransporters are involved

Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport

they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor

and patterning of the developing nervous system

The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells

Required for the fusion of plasma membranes and early endosomes

FA83H Rabbit Polyclonal Antibody, 50ul Enzyme-Linked Immunosorbent Assay (ELISA) Sodium bicarbonate cotransporters are involvedThe protein encoded by this gene plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a cause of amelogenesis imperfecta type 3 (AI3).