LDK378 - CAS# 1032900-25-6 rary of Histone Methyltransferase Chemical Name: benzyl(2-chloroethyl)(1-phenoxypropan-2-yl)amine hydrochloride

Chemical Name: benzyl(2-chloroethyl)(1-phenoxypropan-2-yl)amine hydrochloride

Smiles: CCN(CCOC1C=CC(=CC=1)C(=C(Cl)C1C=CC=CC=1)C1C=CC=CC=1)CC

Guanidine hydrochloride at low concentrations refolds acid-unfolded apomyoglobin and cytochrome c

540(1-3):24-33

Morrison V

LDK378 - CAS# 1032900-25-6 rary of Histone Methyltransferase Chemical Name: benzyl(2-chloroethyl)(1-phenoxypropan-2-yl)amine hydrochlorideCeritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib. LDK378 blocks the ALK protein and stops it