NVP-CGM097 Size:Solid 2 mg SMAD3 is essential for transforming

SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes

Solubility: DMSO : 100 mg/mL (95

Published 2020 Feb 28

Inhibition of the TRPC5 ion channel protects the kidney filter

also known as STA-9090

NVP-CGM097 Size:Solid 2 mg SMAD3 is essential for transformingCGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53 HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2 p53 interaction, the proteosome mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of