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GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 955365-80-7
GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 955365-80-7
GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 955365-80-7
GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 955365-80-7

GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 955365-80-7

SKU: 16677134906

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GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 955365-80-7GDC 0068, CAS No. 1001264 89 6, is a highly potent, selective, and orally available pan Akt inhibitor, targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. It has >100 fold selectivity over a broad panel of 230 kinases, except PRKG1 and PRKG1 with IC50 of 98 nM and 69 nM. GDC 0068 can effectively block Akt signaling and induce cell cycle arrest in human cancer cell lines in vitro, and exhibit significant efficacy in PTEN and

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Description

955365-80-7

17(9):2997-3004

CAS Number: 587871-26-9

increases β-cell mass and insulin content

Smiles: NC1=CC(=CC=C1)S(=O)(=O)N1CCCN(CC1)S(=O)(=O)C1=CC2OCCOC=2C=C1

GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 955365-80-7GDC 0068, CAS No. 1001264 89 6, is a highly potent, selective, and orally available pan Akt inhibitor, targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. It has >100 fold selectivity over a broad panel of 230 kinases, except PRKG1 and PRKG1 with IC50 of 98 nM and 69 nM. GDC 0068 can effectively block Akt signaling and induce cell cycle arrest in human cancer cell lines in vitro, and exhibit significant efficacy in PTEN and

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