Vadimezan (DMXAA) lase is a novel potent and

is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC50 ~ 0

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM)

Molecular Weight: 279

Di Giorgio C

Meisterhans C

Vadimezan (DMXAA) lase is a novel potent andVadimezan, also known as DMXAA and ASA404, is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti tumor activity of tumor associated macrophages. Product information CAS Number: 117570 53 3 Molecular Weight: 282. 29