PF-543 478 Toh et al (2015) A

Toh et al (2015) A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO

RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM)

PF 3716556

Amikin sulfate

8(8):e72641

PF-543 478 Toh et al (2015) APF 543 is a novel selective SK 1 inhibitor which inhibited SK 1 activity in a competitive manner with sphingosine. PF 543 inhibits SphK1 with a K(i) of 3. 6 nM, is sphingosine competitive and is more than 100 fold selective for SphK1 over the SphK2 isoform. PF 543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF 543 is the most