Taltobulin - CAS# 228266-40-8 Size:Solid 10 mg CID 25246343

CID 25246343

Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo

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Molecular Weight: 318

Taltobulin - CAS# 228266-40-8 Size:Solid 10 mg CID 25246343Taltobulin, also known as HTI 286 and SPA 110, is a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport based resistance to taxanes. HTI 286 was a potent inhibitor of proliferation (mean IC50 = 2. 5 2. 1 nm in 18 human tumor cell lines) and had substantially less interaction with multidrug resistance protein (P glycoprotein) than currently used antimicrotubule agents, including