Rigosertib - CAS# 592542-59-1 Catalog No.:M10594-10 OPN and SPP1 are significantly

OPN and SPP1 are significantly lower in the OVX + ODN-h group than in the OVX + Veh group (p < 0

Smiles: CC(C)OC(=O)[C@H](C)N[P@@](=O)(OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(F)[C@@H]1O)OC1=CC=CC=C1

with IC50 values between 0

5-3(6)1-2-4(7)8/h2-9

Novitskiy SV

Rigosertib - CAS# 592542-59-1 Catalog No.:M10594-10 OPN and SPP1 are significantlyRigosertib (ON 01910 sodium salt) is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo like kinase 1 inhibitor ON 01910. Na inhibits polo like kinase1 (Plk1), inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other