PS48 - PDK1 Activator. CAS# 1180676-32-7 size:2 mg solid It inhibits JAK1

It inhibits JAK1

14 μM for [3H]glycine binding in vitro and in vivo

Chemical Name: 2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

which is a positive effector of cell growth and survival

Published 2020 Feb 27

PS48 - PDK1 Activator. CAS# 1180676-32-7 size:2 mg solid It inhibits JAK1PS48, CAS No. 1180676 32 7, is a novel PDK1 (phosphoinositide dependent protein kinase 1) activator (Kd = 10. 3 M), which binds to the HM PIF binding pocket rather than the ATP binding site. PS48 has been used to enhance iPSC reprogramming from human epidermal keratinocytes and endothelial cells. Product information CAS Number: 1180676 32 7 Molecular Weight: 286. 75 Formula: C17H15ClO2 Synonym: PS 48 Chemical Name: 5 (4 Chloro phenyl) 3 phenyl pent 2