DMH-1 - CAS# 1206711-16-1 0197 is a fibroblast growth factor

is a fibroblast growth factor receptor 4 (FGFR4) inhibitor potentially for the treatment of hepatocellular carcinoma and cholangiocarcinoma

34(1):58-61

indicating that the drug directly interacts with tubulin at the colchicine-binding site

InChi: InChI=1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H

Each library comes with a compound list in Excel sheet

DMH-1 - CAS# 1206711-16-1 0197 is a fibroblast growth factorDMH 1, CAS No. 1206711 16 1, is a second generation small molecule BMP inhibitor based on dorsomorphin. DMH 1 effectively inhibits the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Treatment with DMH1 reduced lung metastasis and the tumors were less proliferative and more apoptotic. In the surrounding tumor microenvironment, treatment with DMH1 altered fibroblasts, lymphatic vessels and macrophages to be less tumor promoting. These