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BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 Smiles: CC(C)(C)C1NC2=C(N=1)C1C=CNC(=O)C=1C1=CC(F)=CC=C12

BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 Smiles: CC(C)(C)C1NC2=C(N=1)C1C=CNC(=O)C=1C1=CC(F)=CC=C12

Name: BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 Smiles: CC(C)(C)C1NC2=C(N=1)C1C=CNC(=O)C=1C1=CC(F)=CC=C12
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BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 Smiles: CC(C)(C)C1NC2=C(N=1)C1C=CNC(=O)C=1C1=CC(F)=CC=C12BAY 87 2243, CAS No. 1227158 85 1, is a highly potent and selective inhibitor of hypoxia induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87 2243 mproves local tumor control after fractionated irradiation in a schedule dependent manner in head and neck human xenografts. BAY 87 2243 markedly decreased nuclear HIF 1 expression and pimonidazole hypoxic fraction already after 3 days of drug treatment.

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Smiles: CC(C)(C)C1NC2=C(N=1)C1C=CNC(=O)C=1C1=CC(F)=CC=C12

and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells

Bornmann W

2ClH/c26-23(27)20-8-6-18(7-9-20)16-25-12-10-17(11-13-25)15-24-22-14-21(22)19-4-2-1-3-5-19

Hahka-Kemppinen M

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