LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 is a proinflammatory receptor

is a proinflammatory receptor

it displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status

It showed selectivity for Ral relative to the GTPases Ras and RhoA and inhibited tumour xenograft growth to a similar extent to the depletion of Ral using RNA interference

515(7527):443-7

Su-11274 exhibits a selective inhibition pattern toward different receptor mutated variants

LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 is a proinflammatory receptorLY294002, CAS No. 154447 36 6, is a potent and selective small molecule PI3K inhibitor, inhibits PI3K with IC50 of 0. 5 M, 0. 57 M and 0. 97 M, respectively. It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3 kinases in the signal transduction pathways involved in cell migration, proliferation, survival, and metabolism. LY294002 inactivates Akt PKB, consequently inhibiting cell proliferation and inducing apoptosis. It is