Thalidomide 3845 Identification of pharmacological inhibitors of

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

3-c]pyrimidin-5-amine

Epub 2019 Feb 22

a bitter compound found in citrus

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Thalidomide 3845 Identification of pharmacological inhibitors ofThalidomide is a synthetic derivative of glutamic acid (alpha phthalimido glutarimide) with teratogenic, immunomodulatory, anti inflammatory and anti angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In