JNK-IN-8 - CAS# 1410880-22-6 Catalog No.:M6416-10 The histone deacetylase inhibitor MS-275

The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1

Compared with control (vehicle-treated) tumors

acting as an antagonist of Smoothened

PubMed Central PMCID: PMC4752338

Katayama R

JNK-IN-8 - CAS# 1410880-22-6 Catalog No.:M6416-10 The histone deacetylase inhibitor MS-275JNK IN 8, also known as JNK Inhibitor XVI, CAS No. 1410880 22 6, is a selective JNK inhibitor that inhibits phosphorylation of c Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue. Extensive biochemical, cellular, and pathway based profiling establish the selectivity of JNK IN 8 for JNK and suggests that the compound will be broadly useful as a