NVP-BSK805 Catalog No.:M7922-10 exhibiting 50% inhibitory concentrations (IC50s)

exhibiting 50% inhibitory concentrations (IC50s) of 1

18-pentaoxo-1

InChi: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7

InChiKey: GBWAAJJGXQJTTA-YMYRZEKGSA-N

951 are approximately 2000-fold selective for the glycine binding site relative to the glutamate recognition sites

NVP-BSK805 Catalog No.:M7922-10 exhibiting 50% inhibitory concentrations (IC50s)NVP BSK805 is a JAK2 inhibor, which displays more than 20 fold selectivity towards JAK2 in vitro, as well as excellent selectivity in broader kinase profiling. In vivo, NVP BSK805 exhibited good oral bioavailability and a long half life. The inhibitor was efficacious in suppressing leukemic cell spreading and splenomegaly in a Ba F3 JAK2(V617F) cell driven mouse mechanistic model. Furthermore, NVP BSK805 potently suppressed recombinant human