PHA-665752 Catalog No.:M7762-10 Smiles: CC1=CN=C(NS(=O)(=O)C2=CC=CN=C2C2C=CC(=CC=2)C2=NN=CO2)C(=N1)OC

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PHA-665752 Catalog No.:M7762-10 Smiles: CC1=CN=C(NS(=O)(=O)C2=CC=CN=C2C2C=CC(=CC=2)C2=NN=CO2)C(=N1)OCPHA665752 is a potent and selective inhibitor of c Met HGF SF (IC50 values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk 1, c abl, FGFR1, EGFR and c src respectively). PHA 665752 suppresses the hepatocyte growth factor induced cell proliferation and radioresistance in nasopharyngeal carcinoma cells. PHA 665752 reverses lung premalignancy induced by mutant K ras. PHA 665752 induced apoptosis of a lung adenocarcinoma cell line derived

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